Anna is the largest community and retail trade center in Union County, Illinois, United States. Located in Southern Illinois, its population was 4,442 at the 2010 United States Census, a decline from 5,135 in 2000. It is known for being tied to its close neighbor Jonesboro, together known as Anna-Jonesboro. Anna is known for the Choate Mental Health and Development Center, a state facility that opened in 1869.
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